Journal
TOXICOLOGICAL SCIENCES
Volume 150, Issue 2, Pages 292-300Publisher
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfv325
Keywords
heavy metals; brain; cerebral spinal fluid; amyloid beta; neurodegenerative disease
Categories
Funding
- NTP [HHSN27320100003C]
- Division of Intramural Research and Division National Toxicology Program, National Institute of Environmental Health Sciences [1Z01ES101623, ES021164]
- National Cancer Institute [ZIA BC 011476]
- Joseph and Kathleen Bryan Alzheimer's Disease Research Center [NIA P30AG028377]
Ask authors/readers for more resources
An essential metal hypothesis for neurodegenerative disease suggests an alteration in metal homeostasis contributing to the onset and progression of disease. Similar associations have been proposed for nonessential metals. To examine the relationship between metal levels in brain tissue and ventricular fluid (VF), postmortem samples of frontal cortex (FC) and VF from Alzheimer's disease (AD) cases and nondemented elderly subjects were analyzed for arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), iron (Fe), lead (Pb), manganese (Mn), mercury (Hg), nickel (Ni), tin (Sn), vanadium (V), and zinc (Zn) using inductively coupled plasma sector field mass spectrometry. All metals, with exception of equivalent Pb levels, were lower in the VF, compared to FC. Within-subject comparisons demonstrated that VF levels were not representative of levels within brain tissue. The essential metals Cu, Fe, and Zn were found highest in both compartments. Cd, Hg, and V levels in the VF were below the limit of quantification. In AD cases, FC levels of Fe were higher and As and Cd were lower than levels in controls, while levels of As in the VF were higher. Parameter estimates for FC metal levels indicated an association of Braak stage and higher Fe levels and an association of Braak stage and lower As, Mn, and Zn levels. The data showed no evidence of an accumulation of nonessential metals within the AD brain and, with the exception of As, showed no significant shift in the ratio of FC to VF levels to indicate differential clearance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available