Journal
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
Volume 74, Issue 4, Pages 228-233Publisher
KARGER
DOI: 10.1159/000341096
Keywords
Nasopharyngeal carcinoma; Intensity-modulated radiotherapy; Sensorineural hearing loss; Osteoradionecrosis
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Objective: To assess the long-term audiological outcome and otological complications of nasopharyngeal carcinoma patients who have received intensity-modulated radiotherapy (IMRT) versus conventional two-dimensional radiotherapy (2 DRT). Study Design: Prospective study on the audiological outcome and otological complications 5-9 years after radiotherapy. Methodology: Patients had pure-tone audiogram before radiotherapy and 5 years after radiotherapy. Otological examination was performed 5-9 years after radiotherapy by an otolaryngologist. Results: There is a significant deterioration of the hearing threshold 5 years after radiotherapy but there is no statistically significant difference in the deterioration of hearing between IMRT and 2 DRT. Six patients in the 2 DRT group and 1 patient in the IMRT group had osteoradionecrosis of the external auditory canal (p = 0.042). Conclusion:There are fewer incidences of osteoradionecrosis of the external auditory canal in patients treated with IMRT. There is no difference in bone conduction threshold in patients treated with IMRT or 2 DRT. Copyright (C) 2012 S. Karger AG, Basel
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