Journal
ORGANOMETALLICS
Volume 33, Issue 20, Pages 5781-5790Publisher
AMER CHEMICAL SOC
DOI: 10.1021/om500329q
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- Princeton [CHE-1265988]
- Merck [CHE-1265988]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1265988] Funding Source: National Science Foundation
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The activity of bis(phosphine) iron dialkyl complexes for the asymmetric hydrogenation of alkenes has been evaluated. High-throughput experimentation was used to identify suitable ironphosphine combinations using the displacement of pyridine from py(2)Fe(CH2SiMe3)(2) for precatalyst formation. Preparative-scale synthesis of a family of bis(phosphine) iron dialkyl complexes was also achieved using both ligand substitution and salt metathesis methods. Each of the isolated organometallic iron complexes was established as a tetrahedral and hence high-spin ferrous compound, as determined by Mossbauer spectroscopy, magnetic measurements, and, in many cases, X-ray diffraction. One example containing a Josiphos-type ligand, (SL-J212-1)Fe(CH2SiMe3)(2), proved more active than other isolated iron dialkyl precatalysts. Filtration experiments and the lack of observed enantioselectivity support dissociation of the phosphine ligand upon activation with dihydrogen and formation of catalytically active heterogeneous iron. The larger six-membered chelate is believed to reduce the coordination affinity of the phosphine for the iron center, enabling metal particle formation.
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