Discrete O-Lactate and β-Alkoxybutyrate Aluminum Pyridine-Bis(naphtholate) Complexes: Models for Mechanistic Investigations in the Ring-Opening Polymerization of Lactides and β-Lactones

Methyl aluminum(III) complexes {ONOSiR3}AlMe (SiR3 = SiPh3 (2a), SiMe(2)tBu (2b)) were synthesized by reaction of AlMe3 with pyridinebis(naphthol) proligands {ONOSiR3}H-2 (1a,b) having bulky o-SiR3 substituents on the naphthol groups. Complexes 2a,b were converted into the Al isopropoxide, O-lactate, and beta-alkoxybutyrate complexes {ONOSiR3}AlOR' (R' = iPr (3a), (S)-CH(Me)CO(2)iPr (4a,b), (R)-CH(Me)CH2CO2Me (5a), rac-CH(CF3)-CH2CO2Et (6a)) by reaction with the corresponding alcohol and alpha- and beta-hydroxy esters R'OH.CH...pi? close contacts between the SiPh3 phenyl groups and hydrogens of the methine, methylene, and alkyl ester groups were evidenced by X-ray diffraction studies (for 2a and 4a6a) and by solution NMR. In contrast to the case for (S)-4b, (S)-4a interacts reversibly with racemic lactide (rac-LA) in toluene-d(8) at 20 degrees C, discriminating the l and d monomers, yet without forming isolable six-coordinated adducts. NMR monitoring of the reaction of (S)-4a with l-LA in CD2Cl2 at room temperature allowed identifying the propagation product 7a, as a result of propagation being faster than insertion. The same propagating species formed upon reaction of (S)-4a with l-LA in toluene-d(8) at 80 degrees C. Conversely, the reaction of (R)-5a and l-LA in CD2Cl2 eventually allowed catching the very first insertion product 8a. These observations imply that insertion of LA proceeds more easily into a six-membered Al beta-alkoxybutyrate species than into a five-membered Al O-lactate species.