Journal
ORGANOMETALLICS
Volume 30, Issue 16, Pages 4432-4436Publisher
AMER CHEMICAL SOC
DOI: 10.1021/om2005222
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Funding
- EC
- EaStCHEM School of Chemistry
- Royal Society
- Engineering and Physical Sciences Research Council [1098464] Funding Source: researchfish
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The efficient preparation of [Pd(Amphos)(cinnamyl)Cl)] and [Pd(Amphos)(TFA)(kappa(2)-N,C-C6H4-CH2-NMe2)] (Amphos = 4-(di-tert-butylphosphino)-N,N-dimethylaniline and TFA = trifluoroacetate), two new well-defined palladium precatalysts, is reported. These complexes prove highly active in the Buchwald-Hartwig amination reaction, allowing the coupling of a wide range of (hetero)aryl chlorides, including unactivated, neutral, and sterically hindered substrates, with a wide range of amines, including primary and secondary amines. Finally, the catalytic systems have proven efficient at low catalyst loadings ranging from 0.1 to 0.3 mol %.
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