4.5 Article

Photoinduced DNA and Protein Cleavage Activity of Ferrocene-Appended L-Methionine Reduced Schiff Base Copper(II) Complexes of Phenanthroline Bases

Journal

ORGANOMETALLICS
Volume 28, Issue 7, Pages 1992-1994

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/om900012b

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Funding

  1. Department of Science and Technology
  2. Council of Scientific and Industrial Research (CSIR), New Delhi [SR/S5/MBD-02/2007, 01-2081/06/EMR-11]
  3. Alexander von Humboldt Foundation
  4. J. C. Bose National Fellowship

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Ferrocene-appended ternary copper(H) complexes of phenanthroline bases having CuN3OS coordination with an axial Cu-S bond derived from L-methionine reduced Schiff base shows red light induced oxidative DNA cleavage activity following a hydroxyl radical pathway. The dipyridophenazine complex, in addition, displays photoinduced oxidative cleavage of bovine serum albumin protein in UV-A light.

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