Journal
TISSUE ENGINEERING PART B-REVIEWS
Volume 21, Issue 3, Pages 298-313Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2014.0290
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Funding
- European Union [263289, 251385]
- Science Foundation Ireland, Research Frontiers Programme [09/RFP/ENM2483]
- Health Research Board, Health Research Awards Programme [HRA_POR/2011/84]
- Covidien Research Project [81952]
- Science Foundation Ireland (SFI) [09/RFP/ENM2483] Funding Source: Science Foundation Ireland (SFI)
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Collagen-based devices, in various physical conformations, are extensively used for tissue engineering and regenerative medicine applications. Given that the natural cross-linking pathway of collagen does not occur in vitro, chemical, physical, and biological cross-linking methods have been assessed over the years to control mechanical stability, degradation rate, and immunogenicity of the device upon implantation. Although in vitro data demonstrate that mechanical properties and degradation rate can be accurately controlled as a function of the cross-linking method utilized, preclinical and clinical data indicate that cross-linking methods employed may have adverse effects on host response, especially when potent cross-linking methods are employed. Experimental data suggest that more suitable cross-linking methods should be developed to achieve a balance between stability and functional remodeling.
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