Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 22, Issue 9, Pages 1312-1317Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.8b00196
Keywords
adipic acid; metal-free reaction; oxidation; organocatalysis; radical
Categories
Funding
- MEXT [26105746]
- JSPS [16K08167]
Ask authors/readers for more resources
A direct metal-free approach for the production of adipic acid from cyclohexane is reported. The use of N-hydroxyphthalimide (NHPI) as a catalyst in the presence of HNO3/TFA enables the direct oxidation of cyclohexane to yield adipic acid under ambient temperature and pressure via a simple procedure. This reaction proceeds through an initial oxidation of cyclohexane to cyclohexanone oxime and cyclohexanone followed by a second oxidation of these intermediates to adipic acid. NHPI plays a crucial role in both oxidation steps to achieve a high yield and selectivity for adipic acid.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available