Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 18, Issue 12, Pages 1836-1842Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op500260n
Keywords
-
Categories
Funding
- AbbVie Inc.
Ask authors/readers for more resources
Thermal hazard analyses of two reactions, one with DMSO as the solvent and a reactant and one with DMSO as the solvent and a byproduct, identified low-probability but severe consequence process risks associated with violent decomposition of DMSO during heating control failure or external heating. Although DMSO cannot be totally eliminated from these reactions, using an alternative solvent to replace DMSO proved to be an effective measure in reducing the thermal hazards to allow safe scale-up.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available