Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 18, Issue 7, Pages 897-903Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op500129e
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Funding
- Central Innovation Program SME (Zentrales Innovationsprogramm Mittelstand, ZIM) of the Federal Ministry for Economic Affairs and Energy (Bundesministerium fur Wirtschaft und Technologie, BMWi) [KF2622302AJ2]
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A recombinant isoenzyme of pig liver esterase was used for the highly enantioselective desymmetrization of dimethyl cyclohex-4-ene-cis-1,2-dicarboxylate. The selected recombinant esterase showed a significant advantage in enantioselectivity over the commonly used esterase from the mammalian source. The process was scaled up to yield 265 g of product with a simplified pH control, and the target molecule was obtained with an enantiopurity of >99.5% ee.
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