Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 18, Issue 1, Pages 109-121Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op4002774
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This publication describes the evaluation of four synthetic routes to the advanced pregabalin (Lyrica) intermediate 7. Asymmetric reduction of (E)-7 with an ene-reductase (OPR1 from Lycopersicon esculentum) gave a saturated cyanoester intermediate 5 with the desired S stereocenter in >99% ee. OPR1 also catalyzed the reduction of (Z)-7 to (S)-5, but with lower conversion and selectivity.
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