Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 17, Issue 3, Pages 397-405Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op300364p
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Funding
- EPSRC
- Royal Society
- EPSRC [EP/K03927X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K03927X/1] Funding Source: researchfish
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The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.
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