Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 17, Issue 6, Pages 927-933Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op400085a
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Funding
- Novartis MIT Center for Continuous Manufacturing
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The tube-in-tube reactor is a convenient method for implementing gas/liquid reactions on the microscale, in which pressurized gas permeates through a Teflon AF-2400 membrane and reacts with substrates in liquid phase. Here we present the first quantitative models for analytically and numerically computing gas and substrate concentration profiles within the tube-in-tube reactor. The model accurately predicts mass transfer performance in good agreement with experimental measurement. The scaling behavior and reaction limitations of the tube-in-tube reactor are predicted by modeling and compared with gas/liquid micro- and minireactors. The presented model yields new insights into the scalability and applicability of the tube-in-tube reactor.
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