Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 16, Issue 9, Pages 1566-1568Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op300164y
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A novel synthetic route for commercial preparation of cinacalcet hydrochloride (1), a calcimimetic agent and calcium-sensing receptor antagonist, is described. Our synthetic approach involves the preparation of cinacalcet using C-C bond formation catalyzed by iron acetylacetonate/NMP complex with aryl Grignard reagent benzotrifluoride magnesium bromide (8) and alkenyl halide N-chloropropene naphthylethylamine (6).
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