Fast Scale-Up Using Microreactors: Pyrrole Synthesis from Micro to Production Scale

A flow chemistry method for the synthesis of pyrroles was developed. The method was optimized in 0.13 to 7 mu L microreactors in continuous flow, reaching yields of nearly 100%. Subsequently, the method was scaled up in continuous flow using a 9.6-mL internal volume, glass, microstructured flow reactor, leading to production of a pyrrole derivative at a rate of 55.8 g per hour.