Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 16, Issue 1, Pages 166-171Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op200234j
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A ruthenium catalyst for the reduction of esters by hydrogenation has been developed. Processes for the hydrogenation of esters have also been developed for (R)-1,2-propanediol and 2-(I-menthoxy)ethanol. The catalyst shows good catalytic activity for the hydrogenation of esters in methanol. Methyl lactate was reduced at 30 C and gave turnover numbers (TON) up to 4000. The optical purity of the (R)-1,2-propanediol made by the hydrogenation of methyl (R)-lactate was higher than that via the asymmetric hydrogenation of hydroxyacetone. A hydrogenation process to replace the lithium aluminum hydride (LAB) reduction used in the production of 2-(I-menthoxy)ethanol was developed.
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