Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 15, Issue 6, Pages 1305-1314Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op200181f
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The development of a synthetic process for (S,S)-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination. This entailed evaluation of several alternative routes to result in what would have been a commercially attractive process for launch of the compound.
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