Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 14, Issue 4, Pages 1046-1049Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op100024j
Keywords
-
Categories
Funding
- EPSRC [EP/F038321/1]
- Piramal Healthcare
- EPSRC [EP/F038321/1, EP/F037643/1, EP/F015690/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F015690/1, EP/F038321/1, EP/F037643/1] Funding Source: researchfish
Ask authors/readers for more resources
The use of [Cp*IrI2](2) as an efficient catalyst for the alkylation of amines by alcohols in either water or ionic liquid is described. Primary amines are converted into secondary amines, and secondary amines into tertiary amines in the absence of base, and the chemistry has been applied to the synthesis of the analgesic fentanyl. The conversion of primary amines into N-heterocycles by the reaction with diols is also described, along with the N-alkylation of sulfonamides.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available