Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 14, Issue 4, Pages 939-941Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op100094p
Keywords
-
Categories
Ask authors/readers for more resources
An improved palladium(II)-catalyzed cleavage of the allyl group in allyl faropenem 2 into faropenem sodium 1 is described. The development of an efficient method for the removal of palladium impurities from the crude product 1 upon treatment with polystyrene-bound 2,4,6-trimercapto-s-triazine (polystyrene-bound TMT) led to a drastic decrease of residual palladium level from 1500-1600 ppm to less than 10 ppm in the final isolated product. The palladium(II)-catalyzed cleavage and palladium removal process demonstrated on 10 kg scale are highly convenient and efficient.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available