Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 14, Issue 1, Pages 114-118Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op900207n
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- ICES Ltd, Singapore
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An efficient enzymatic process based on HNL-CLEA catalysis in buffer-saturated organic media was developed to limit the amount of overall waste generated and the number of safety issues incurred by handling HCN-containing waste. Starting front benzaldehyde as a model substrate, (R)- and (S)-mandelonitrile can be obtained under these reaction conditions without in extraction step being required. The crude cyanohydrin intermediate was sufficiently pure to be used as starting material in a second step towards a range of derivatives.
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