Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 14, Issue 1, Pages 152-158Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op900252a
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The copper-catalyzed click reaction of an azide with an alkyne has become a popular method to build tip 1,4-substituted 1H-1,2,3-triazoles in medicinal chemistry and this approach was used on a laboratory scale during the preparation of novel macrolide 1. However, the manufacture of the key azide component, as well as its subsequent use in the presence of a copper catalyst on a large scale, was associated with potential safety concerns. Therefore, a sequence was developed in which construction of the 1,4-substituted 1H-1,2,3-triazole in 1 was accomplished via cyclocondensation of an alpha,alpha-dichloro tosyl hydrazone with an amine.
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