4.6 Article

A Convergent Synthesis of AR-C123196 Utilising Reaction Between a Cyclic Carbonate and a Phenol for Aryl Alkyl Ether Formation

Journal

ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 13, Issue 4, Pages 751-759

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/op9000687

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The development of a convergent synthesis of AR-C123196 is reported in which the alkyl aryl ether linkage was formed by nucleophilic attack of a phenolic hydroxyl group onto a cyclic carbonate. This approach was successfully operated on a multikilogram scale.

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