Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 12, Issue 2, Pages 298-300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op700286u
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An efficient synthesis of enantiopure Fmoc-alpha-methylvaline has been developed. The racemate was prepared in two steps from 3-methyl-2-butanone and was resolved using a chiral amine, (S)1,2,3,4-tetrahydro-1-naphthylamine to give the desired, enantiopure S-isomer in 23% overall yield.
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