Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 12, Issue 4, Pages 674-677Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op800107u
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The use of microscale HPLC for piloting the large-scale preparative chromatographic resolution of the enantiomers of a chiral pharmaceutical intermediate is reported with an example of a millionfold scale-up from a 300 mu m i.d. column to a 30 cm W column. Performance and productivity at scale are accurately predicted by the microscale approach, which consumes only a small fraction of the material typically used for conventional loading studies. These results suggest a great potential for use of microscale HPLC loading studies during early synthetic route investigations, when only a small amount of sample is typically available.
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