Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 12, Issue 5, Pages 1001-1006Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op800025p
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Funding
- EPSRC (RAIS Award)
- The University of Hull
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Initial steps have been taken to develop an integrated microreactor, capable of performing multicomponent reactions consisting of both solution phase and heterogeneously catalyzed steps. Using the multicomponent Strecker reaction as a model, five alpha-aminonitriles were synthesized in excellent yields (> 99.5%) and analytical purity, under continuous flow conditions.
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