Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 12, Issue 5, Pages 929-939Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op800071m
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The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.
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