Journal
ORGANIC LETTERS
Volume 20, Issue 19, Pages 6284-6288Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02785
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Funding
- National Natural Science Foundation of China [21672121, 21871160]
- Thousand Plan Youth Program of China, Tsinghua University
- Bayer Investigator Fellow
- Fellowship of the Tsinghua-Peking Centre for Life Sciences (CLS)
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The unprecedented ruthenium-catalyzed atropoenantioselective reductive amination of aldehydes with alkylamines via a cascade transfer hydrogenation and dynamic kinetic resolution strategy is described. This protocol features broad substrate scope and good functional group tolerance and allows the rapid assembly of axially chiral biaryls in good to high yields with high to excellent enantioselectivities. In addition, such structural motifs may have potential applications in enantioselective catalysis as chiral ligands or catalysts.
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