Journal
ORGANIC LETTERS
Volume 20, Issue 18, Pages 5866-5871Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02538
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Funding
- National Natural Science Foundation of China [21672121, 21871160]
- Thousand Plan Youth Program of China
- Tsinghua University
- Bayer
- Fellowship of Tsinghua-Peking Centre for Life Sciences (CLS)
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The N-heterocyclic carbene (NHC)-catalyzed enantioselective kinetic resolution of anilides (a kind of hemiaminals) is reported. Upon exposure to the reaction in the presence of an NHC precatalyst and base, catalytic C-O bond formation occurs, providing axially chiral isoindolinones in high yields with excellent enantioselectivities.
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