Journal
ORGANIC LETTERS
Volume 20, Issue 18, Pages 5899-5904Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02551
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Funding
- National Natural Science Foundation of China [21602067]
- Huazhong University of Science and Technology [2016YXMS183]
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A novel synergistically catalyzed thia-aza-Prins cyclization of alkenylamines with disulfides is reported, rendering the first synthesis of sulfenylated 1,3-oxazinanes and oxazolidines in good to high yields. Importantly, DMSO serves simultaneously as a reaction medium and a surrogate for formaldehyde. Mechanistic studies provide evidence that actions of CuBr2 and in situ formed sulfinic acids as a Lewis acid and Bronsted acid catalyst, respectively, synergistically catalyze these cyclization processes.
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