Journal
ORGANIC LETTERS
Volume 20, Issue 18, Pages 5597-5600Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02272
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Funding
- Jilin Province Natural Science Foundation [20160519003JH]
- Changbai Mountain Scholarship Program
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Copper-catalyzed cascade aminoalkynylation-oxidation of propargylic alcohols has been realized, sterospecifically providing an array of (Z)-2-amino conjugated enynals/enynones in good yields under mild conditions. This transformation involves a rare 1,3-alkynyl migration of propargylic alcohols and simultaneously forms C-C, C-N, and C=O bonds. Furthermore, (Z)-2-amino conjugated enynals were applied to efficiently synthesize 3,5-disubstituted-1H-pyrrole-2-carbaldehyde and conjugated enynol derivatives.
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