Journal
ORGANIC LETTERS
Volume 20, Issue 19, Pages 6148-6152Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02617
Keywords
-
Categories
Funding
- Australian Research Council (ARC) Discovery Project [DP170100228]
- Australian Government International Postgraduate Research Scholarship
Ask authors/readers for more resources
A biosynthetic gene cluster that is significantly upregulated in the fungal wheat pathogen Parastagonospora nodorum during plant infection was reconstructed heterologously in Aspergillus nidulans. This led to the discovery of five new alpha-pyrone polyketides, alternapyrones B-F (2-6). Compounds 5 and 6, which contain a highly substituted dihydrofuran, exhibited phytotoxicity on wheat seed germination. It is demonstrated that only three enzymes, one highly reducing polyketide synthase and two multifunctional P450 oxygenases, are needed to synthesize the structurally complex products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available