Journal
ORGANIC LETTERS
Volume 20, Issue 19, Pages 6046-6050Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02422
Keywords
-
Categories
Funding
- National Cancer Institute/NIH, Bethesda, MD, USA [P01 CA125066]
- NATIONAL CANCER INSTITUTE [P01CA125066] Funding Source: NIH RePORTER
Ask authors/readers for more resources
A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available