Journal
ORGANIC LETTERS
Volume 20, Issue 16, Pages 4959-4963Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02087
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Funding
- Scientific Research Foundation of China [21402016]
- Chongqing Science and Technology Commission [cstc2017zdcy-adyfX0022]
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A simultaneous asymmetric Mannich reaction and the construction of axially chiral sulfone-containing styrenes in one pot from alpha-amido sulfones based on the waste-reuse strategy was demonstrated. A series of chiral beta-amino diesters and axially chiral sulfone-containing styrenes with various functional groups were synthesized in good to excellent yields and enantioselectivities under mild conditions. In addition, this protocol has been successfully applied to synthesize the anti-HIV drug Maraviroc and chiral trichloro derivatives.
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