Bioactive Injectables Based on Calcium Phosphates for Hard Tissues: A Recent Update

Self-gelling/setting injectable biomaterials hold great promise for the delivery of bioactive molecules and cells useful for tissue engineering and regenerative medicine. In the biopolymeric regime, a broad compositional spectrum has been developed, yet very limited compositional options have been developed for inorganic injectables. For example, calcium phosphate (CaP)-based injectables are considered to be one of the most promising classes of materials for bone repair and reconstruction. Here we present an update on the recent advancements in CaP-injectables, where significant efforts have been undertaken to improve the regenerative capacity by tailoring the chemical compositions and increasing the drug delivery potential.