4.8 Article

Rhodium-Catalyzed Direct C-H Bond Cyanation in Ionic Liquids

Journal

ORGANIC LETTERS
Volume 20, Issue 16, Pages 4994-4997

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01952

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Funding

  1. National Natural Science Foundation of China (NSFC) [81573286, 81773577]

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A Cp*Rh(III)/IL-based direct C-H bond cyanation system was developed for the first time. The system is a mild, efficient, and recyclable method for the synthesis of aryl nitriles. Many different directing groups can be used in this cyanation, and the reaction tolerates a variety of functional groups.

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