4.8 Article

Nickel-Catalyzed Csp2-Csp3 Bond Formation via C-F Bond Activation

Journal

ORGANIC LETTERS
Volume 20, Issue 18, Pages 5644-5647

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02351

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Funding

  1. DAAD
  2. Kekule fellowship (Fonds der Chemischen Industrie)
  3. Studienstiftung des Deutschen Volkes

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A nickel-catalyzed cross coupling of aryl fluorides via C-F bond activation has been developed. The alkylation method allows selective replacement of aryl fluorides by alkyl groups and enables the synthesis of diverse and otherwise difficult to access scaffolds in good yields.

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