Journal
ORGANIC LETTERS
Volume 20, Issue 15, Pages 4499-4503Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01799
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- Indian Institute of Science
- UGC
- CSIR
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NHC-catalyzed enantioselective [3 + 3] spiro-annulation of alpha,beta-unsaturated aldehydes with cyclic beta-ketoamides allowing the preparation of synthetically and biologically important spiro-glutarimide derivatives has been reported. The interception of the ketoamides with catalytically generated chiral alpha,beta-unsaturated acylazoliums proceeds in a Michael addition-intramolecular amidation pathway to deliver the spirocyclic products with good yield, diastereoselectivity, and enantioselectivity.
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