Journal
ORGANIC LETTERS
Volume 20, Issue 15, Pages 4486-4489Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01787
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Funding
- National Natural Science Foundation of China [21325207, 21532003, 21421062]
- 111 project of the Ministry of Education of China [B06005]
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A green and efficient iridium-catalyzed asymmetric transfer hydrogenation of alkynyl ketones to chiral propargylic alcohols has been developed. By using sodium formate and ethanol as hydrogen sources, a series of alkynyl ketones were hydrogenated by chiral spiro iridium catalyst (S)-1b to provide optically active chiral propargylic alcohols with up to 98% ee under base-free conditions. This protocol provides a practical and sustainable method for the preparation of optically active propargylic alcohols.
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