Journal
ORGANIC LETTERS
Volume 20, Issue 17, Pages 5398-5401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02309
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Funding
- National Natural Science Foundation of China [21472037, 21672055, 21602045]
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A direct route to chiral six-membered carbocyclic purine nucleoside analogues with three chiral stereocenters, including a chiral tetrasubstituted carbon center, via a highly enantioselective [3 + 3] annulation has been established. With the application of Takemoto's catalyst, various chiral six-membered carbocyclic purine nucleoside analogues were obtained in high yields (up to 89%) with moderate to good diastereoselectivities (up to 90:10 dr) and excellent enantioselectivities (92-98% ee). Furthermore, diverse chiral six-membered carbocyclic purine nucleoside analogues were generated by simple transformations.
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