Journal
ORGANIC LETTERS
Volume 20, Issue 17, Pages 5457-5460Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02377
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Funding
- Joint research project of health and education of Fujian Province [WKJ2016-2-06]
- National Natural Science Foundation of China [81571802]
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Herein, we report a biomimetic oxidative coupling cyclization strategy for the highly efficient functionalization of tetrahydrocarbolines (THCs). This process enables rapid access to complex isochromanoindolenine scaffolds in moderate to excellent yields. The reaction proceeds smoothly and rapidly (complete within minutes) in an open flask. This operationally simple protocol is scalable and compatible with a wide range of functional groups. Late-stage functionalization of a pharmacologically relevant molecule is also demonstrated.
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