Journal
ORGANIC LETTERS
Volume 20, Issue 17, Pages 5198-5202Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02137
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Funding
- Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]
- National Science Fund for Distinguished Young Scholars [81725021]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- National Natural Science Foundation of China [31370372, 21702067, 81602986]
- China Postdoctoral Science Foundation [2017M610479, 2018T110777]
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The structure stability relationships of 1-6 were investigated to show that 1 converted to 5 via a kinetic, solution-mediated autoxidation. In addition, alterbrassicene A (7), a fusicoccane-derived diterpenoid bearing an unprecedented 5/9/4-fused carbocyclic skeleton with a rare fused 2-cyclobuten-1-one motif, was characterized from Alternaria brassicicola. Its absolute structure was elucidated by spectroscopic analyses and quantum chemical calculations. Compound 7 was the first fusicoccane derivative acting as a potent IKK beta inhibitor in the NF-kappa B signaling pathway.
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