Journal
ORGANIC LETTERS
Volume 16, Issue 22, Pages 6020-6023Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol503035z
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- China Scholarship Council (CSC)
- Life Science Network of the German Technion Society (GTS)
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An improved method for the dehydrogenative C-H/C-H cross-coupling at the C-7 position of indolines containing a urea as a directing group is reported. The new protocol is a rare example of an aerobic palladium(II)-catalyzed cross dehydrogenative coupling (CDC) reaction that proceeds at low temperature. The use of either Cu(OAc)(2) in an open flask or dioxygen (balloon) at 50 degrees C tolerates indolines not substituted at C-2 and C-3, thereby extending the scope of the previous method that suffers from indoline-to-indole oxidation.
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