Journal
ORGANIC LETTERS
Volume 16, Issue 18, Pages 4960-4963Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502538r
Keywords
-
Categories
Funding
- MEXT, Japan [22000009]
- JSPS [25708017]
- Grants-in-Aid for Scientific Research [25708017, 14J00435] Funding Source: KAKEN
Ask authors/readers for more resources
The nickel-catalyzed double carboxylation of internal allcynes employing carbon dioxide (CO2) has been developed. The reactions proceed under CO2 (1 atm) at room temperature in the presence of a nickel catalyst, Zn powder as a reducing reagent, and MgBr2 as an indispensable additive. Various internal alkynes could be converted to the corresponding maleic anhydrides in good to high yields. DFT calculations disclosed the indispensable role of MgBr2 in the second CO2 insertion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available