Journal
ORGANIC LETTERS
Volume 16, Issue 20, Pages 5366-5369Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502572g
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Funding
- MOST [2013AA092901]
- NSFC [81121062, 21132004, 21072092]
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The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.
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