Journal
ORGANIC LETTERS
Volume 16, Issue 20, Pages 5390-5393Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502624z
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Funding
- NSFC [21202072, 21102141, 21432003]
- Fundamental Research Funds for the Central Universities [860976, 861188]
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A mild, versatile, and convenient method for efficient intramolecular oxytrifluoromethylthiolation of unactivated alkenes catalyzed by Cu(OAc)(2) has been developed. The reactions were carried out under aerobic conditions and formed a variety of isoxazolines bearing a -SCF3 substituent.
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