4.8 Article

Cobalt-Catalyzed Cyclization of Carbon Monoxide, Imine, and Epoxide

Journal

ORGANIC LETTERS
Volume 16, Issue 8, Pages 2130-2133

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol500549c

Keywords

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Funding

  1. National Natural Science Foundation of China [21104049]
  2. Specialized Research Fund for the Doctoral Program (SRFDP) of Higher Education [20113201120006]
  3. Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
  4. Soochow University Funds [14109001, Q410900510]
  5. Suzhou Industrial Park Fund
  6. National Science Foundation of USA [CHE-1266442]
  7. Direct For Mathematical & Physical Scien
  8. Division Of Chemistry [1266442] Funding Source: National Science Foundation

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Cobalt-catalyzed cyclization of CO, imine, and epoxide has been developed. A convenient catalyst system composed of Co-2(CO)(8) and LiCl is identified, and the substrate scope has been explored. The reaction provides an efficient method for the synthesis of substituted 1,3-oxazinan-4-ones.

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