Journal
ORGANIC LETTERS
Volume 16, Issue 24, Pages 6432-6435Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol503264n
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Funding
- National Natural Science Foundation of China [51373067]
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Bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors have rarely been explored. The first quaternary ammonium type of these catalysts derived from cinchona alkaloids were readily prepared and found to be highly efficient catalysts for asymmetric nitro-Mannich reactions of amidosulfones. Compared with previous reports, very broad substrate generality was observed, and both enantiomers of the products were achieved in high enantio- and diastereoselectivity (90-99% ee, 13:1 to 99:1 dr).
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