4.8 Article

Arylalkene Synthesis via Decarboxylative Cross-Coupling of Alkenyl Halides

Journal

ORGANIC LETTERS
Volume 16, Issue 10, Pages 2664-2667

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol500876x

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Funding

  1. DFG [SFB TRR88]
  2. Chinese Scholarship Council

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A bimetallic catalyst system generated from readily available palladium(II) and copper(I) salts, 1,10-phenanthroline and tri-1-naphthylphosphine was found to efficiently mediate the decarboxylative cross-coupling of alkenyl bromides and chlorides with aromatic carboxylates. It allows the regiospecific synthesis of a broad range of aryl- and heteroarylalkenes in high yields.

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