Journal
ORGANIC LETTERS
Volume 16, Issue 16, Pages 4324-4327Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5020619
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Funding
- Japan Society for the Promotion of the Science [25450145]
- Japan Society for the Promotion of Science Fellowships for young scientists [8696]
- Grants-in-Aid for Scientific Research [25450145, 12J08696] Funding Source: KAKEN
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Total synthesis of callipeltins B and M, peptidyl cytotoxic agents isolated from marine sponges, by the combination of Fmoc solid-phase peptide synthesis and cyclization and global deprotection in the solution phase is described. Eight amino acids, including several unusual amino acids, were assembled on a solid support, and effective TFA-mediated deprotection was employed to reach callipeltin M. Callipeltin B was accomplished via the macrolactonization between the side chain of D-aThr and the C-terminus carboxylic acid of protected callipeltin M.
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