4.8 Article

A Free-Radical Cascade Methylation/CyClization of N-Arylacrylamides and lsocyanides with Dicumyl Peroxide

Journal

ORGANIC LETTERS
Volume 16, Issue 21, Pages 5670-5673

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol502738a

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Funding

  1. National Science Foundation of China [21272096, 21472080]
  2. Fundamental Research Funds for the Central Universities [lzujbky-2014-58]

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A free-radical cascade methylation/cyclization of a wide range of N-arylacrylamides and isocyanides is demonstrated by using dicumyl peroxide as the methylating reagent, which provides a convenient and selective access to various methylated N-heterocycles such as oxindoles and phenanthridines.

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